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Nicotinamide mononucleotide (NMN/ NMN 18000) is a nucleotide found naturally in the body that has potential anti aging effects. This article will explore what NMN/ NMN 18000 is, how it may benefit aging and potential side effects.
What is NMN/ NMN 18000?
NMN/ NMN 18000 stands for Nicotinamide mononucleotide. It is a molecule related to vitamin B3 (niacin/niacinamide) that occurs naturally in all living cells. NMN/ NMN 18000 acts as a precursor to other important molecules like Nicotinamide adenine dinucleotide (NAD+), which is essential for cellular energy production and repair.
As people age, levels of NAD+ in cells tend to decline. This reduction in NAD+ is associated with age related conditions like:
Mitochondria are the energy producers in cells and require NAD+ for optimal function. Lower levels of NAD+ can impair mitochondrial energy production and increase oxidative stress.
NAD+ is needed for DNA repair enzymes to function properly. Lower NAD+ may result in accumulated DNA damage over time.
Senescent cells no longer divide but remain metabolically active and secrete pro-inflammatory signals. NAD+ helps clear senescent cells.
Stem cell exhaustion
Adult stem cells depend on NAD+ to maintain their regenerative potential. Diminished NAD+ can exhaust stem cell pools.
NMN can Increase lifespan
NMN/ NMN 18000 supplementation extended lifespan in mice by around 20%.
NMN can Improve organ function
NMN/ NMN 18000 improved function of organs like the heart, liver, and kidneys in aging mice.
NMN can Enhance metabolic health
NMN/ NMN 18000 reduced blood sugar, cholesterol, and signs of fatty liver in rodent models.
NMN Promotes cognitive benefits
NMN/ NMN 18000 improved memory and reverse signs of brain aging in aged mice.
NMN Potential side effects
Based on current research, NMN/ NMN 18000 appears to be well tolerated with minimal side effects. However, potential risks could include:
Some people have reported nausea, diarrhea and abdominal discomfort with high dose NMN/ NMN 18000 supplements.
As NMN/ NMN 18000 is related to niacin, there is a theoretical risk of rare niacin flush reactions in sensitive individuals.
In summary, NMN/ NMN 18000 appears to be safe at commonly recommended doses of 100 to 250 mg per day. Speak with your healthcare provider before taking NMN/ NMN 18000 supplements.
How NMN/ NMN 18000 may work to slow aging
The proposed mechanisms by which NMN/ NMN 18000 may help counteract signs of aging involve:
Increasing NAD+ levels
By enhancing mitochondrial NAD+ levels, NMN/ NMN 18000 may help restore mitochondrial function and efficiency. This could reduce oxidative stress and improve cellular energy production.
DNA repair activation
Higher NAD+ activates DNA repair enzymes that detect and fix DNA damage before it accumulates. This likely contributes to maintaining genomic stability as we age.
Senescent cell clearance
Immune cells require NAD+ to find and eliminate senescent cells. NMN/ NMN 18000 may assist these immune cells in removing aged cells that promote inflammation.
Stem cell rejuvenation
Adult stem cell function depends on adequate NAD+. NMN/ NMN 18000 may support stem cell activities involved in tissue maintenance and repair.
In summary, by boosting intracellular NAD+ levels, NMN/ NMN 18000 has the potential to target multiple processes involved in aging at the cellular and molecular level.