NMN (nicotinamide mononucleotide) is a popular supplement used by those looking for longevity-promoting and anti-aging effects. NMN / NMN supplement has been shown in studies to boost levels of NAD+ (nicotinamide adenine dinucleotide), an important cellular energy molecule that declines with age.

However, beyond its NAD+-boosting and anti-aging potential, NMN / NMN supplement also has compelling anti-inflammatory effects. Chronic inflammation is at the root of many diseases and negatively impacts health and longevity. The ability of NMN / NMN supplement to reduce inflammatory markers and pathways can have significant benefits for health and wellness.

In this article, we’ll explore the key research showing how NMN / NMN supplement  exert potent anti-inflammatory actions, both in animal models and human cells. By reducing inflammation, NMN / NMN supplement may help alleviate inflammation-related conditions, protect against disease, and support healthier aging.

NMN / NMN supplement Decreases Inflammatory Markers in Aged Mice

One of the key ways NMN / NMN supplement exhibits anti-inflammatory effects is by decreasing levels of inflammatory markers. For example, in a study of aged mice, NMN / NMN supplement supplementation for 8 weeks led to significantly decreased levels of inflammatory cytokines IL-6 and TNF-alpha. These pro-inflammatory cytokines rise with aging and age-related diseases, so reducing them may protect against inflammation-related conditions and frailty.

In the same study, NMN / NMN supplement increased levels of the anti-inflammatory cytokine IL-10 and also boosted synthesis of antimicrobial peptides (AMPs), which help regulate immune responses. Through these effects on inflammatory and anti-inflammatory markers, NMN / NMN supplement supplementation benefited immune function and boosted resilience against infections in the aged mice.

NMN / NMN supplement Lowers NF-kB, a Master Regulator of Inflammation

NF-κB is a major transcription factor that controls the expression of many inflammatory genes and proteins. When activated, NF-κB triggers the release of inflammatory cytokines and other mediators that contribute to chronic inflammation. By inhibiting the NF-κB pathway, inflammation can be dampened and conditions related to excessive inflammation may be improved.

Studies show NMN / NMN supplement is able to inhibit NF-κB activation. For example, in human endothelial cells, NMN / NMN supplement decreased NF-κB activation in response to inflammatory stimuli like TNF-alpha. The reduced NF-κB activity corresponded with lower expression of pro-inflammatory adhesion molecules and cytokines. The researchers concluded that NMN / NMN supplement has significant anti-inflammatory effects mediated by NF-κB suppression.

Other research found that in obese mice fed a high-fat diet, NMN / NMN supplement supplementation for 8-12 weeks significantly lowered NF-κB activation in the liver. This was accompanied by improvements in insulin resistance and other metabolic benefits. The anti-inflammatory effects of NMN / NMN supplement via NF-κB inhibition may help address inflammation-related insulin resistance and metabolic dysfunction.

NMN / NMN supplement Boosts NAD+, Which Also Has Anti-Inflammatory Actions

In addition to NMN / NMN supplement’s direct anti-inflammatory effects, boosting NAD+ levels with NMN / NMN supplement also indirectly contributes to an anti-inflammatory effect. NAD+ itself regulates various inflammatory and immune pathways, and higher NAD+ levels are associated with lower levels of inflammatory markers.

For example, increased NAD+ has been shown to inhibit the NLRP3 inflammasome, a multi-protein complex involved in the production of inflammatory cytokines like IL-1beta and IL-18. Higher NAD+ also promotes the function of regulatory T-cells, which help control excessive inflammation and the immune response. Through these NAD+-mediated effects, NMN / NMN supplement may dampen inflammation and keep immune activity in check.

In summary, NMN / NMN supplement has significant anti-inflammatory potential. It reduces levels of inflammatory cytokines like IL-6 and TNF-alpha, inhibits NF-κB activation, and boosts levels of the anti-inflammatory cytokine IL-10 and antimicrobial peptides. By boosting NAD+ levels, NMN / NMN supplement also contributes to an anti-inflammatory effect through regulating the NLRP3 inflammasome and T-regulatory cells. Due to these potent anti-inflammatory actions, NMN / NMN supplement shows promise for alleviating inflammation-related diseases, supporting healthier aging, and boosting wellness.